49ers vs. Patriots Week 4 Predictions, Odds and Stats

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According to our computer projection model, the San Francisco 49ers will defeat the New England Patriots when the two teams match up at Levi's Stadium on Sunday, Sept. 29, which kicks off at 4:05 p.m. ET. For our projections on the spead, point total, and final score, check out the rest of the article below.

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49ers vs. Patriots Game Info and TV Channel

When: Sunday, September 29, 2024 at 4:05 p.m. ETWhere: Levi's Stadium in Santa Clara, CaliforniaTV: FOXLive Stream: Watch this game on Fubo (Regional restrictions may apply)Catch every NFL touchdown with NFL RedZone on Fubo.

49ers vs. Patriots Odds and Betting Info

Spread favorite: 49ers (-10.5)Moneyline: 49ers (-578), Patriots (+422)Total: 40.5 points

49ers vs. Patriots Prediction

Pick ATS:

Pick Em

Pick OU: Under (40.5)

Prediction:

49ers 25 - Patriots 15

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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49ers vs. Patriots Betting Insights

The 49ers have a record of 1-2-0 against the spread this season.The Patriots have won one game against the spread this season.This season, games featuring the 49ers have hit the over twice.Patriots games have gone over the point total once this year.Looking for NFL tickets? Head to StubHub today and see your team live.