Flyers vs. Sabres Prediction & Picks - Oct. 21

Buffalo Sabres v Montreal Canadiens

Photo: Minas Panagiotakis / Getty Images Sport / Getty Images

The Philadelphia Flyers (2-6-3) take a five-game road losing streak into a matchup against the Buffalo Sabres (4-3-2) on Wednesday, Oct. 21 at 7:30 p.m. ET on TNT.

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Here is our pick for who will clinch the victory in Wednesday's matchup.

Flyers vs. Sabres Predictions for Wednesday

Our computer projections model for this matchup calls for a final result of Sabres 4, Flyers 2.

  • Moneyline Pick: Sabres (-208)
  • Total Pick: Under 6 (computer predicts 5.8 goals on average)
  • Spread Pick: Flyers (+1.5)

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Sabres Splits and Trends

  • The Sabres have gone 2-2-4 in overtime matchups on their way to an overall record of 4-3-2.
  • Buffalo is 3-0-1 (seven points) in its four games decided by one goal.
  • In the one game this season the Sabres registered just one goal, they lost.
  • The Sabres have scored at least three goals in seven games (4-1-2, 10 points).
  • In the only game when Buffalo has recorded a single power-play goal, it lost.
  • In the six games this season in which it has outshot its opponent, Buffalo is 4-2-0 (eight points).
  • The Sabres have been outshot by opponents three times, and went 0-1-2 (two points).

Flyers Splits and Trends

  • The Flyers (2-6-3 overall) have posted a record of -3-3 in matchups that have needed OT this season.
  • Philadelphia has earned four points (1-2-2) in its five games that finished with a one-goal margin.
  • This season the Flyers registered just one goal in five games and they lost every time.
  • When Philadelphia has scored two goals this season, they've earned three points (0-0-3 record).
  • So far this season, the Flyers have scored three or more goals two times and won each of those games.
  • This season, Philadelphia has capitalized on a single power-play goal in four games and picked up four points with a record of 2-2-0.
  • When outshooting its opponent, Philadelphia is 1-1-0 (two points) this season.
  • The Flyers have been outshot by opponents nine times this season, and earned five points in those games.

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Team Stats Comparison

Sabres Rank Sabres AVG Flyers AVG Flyers Rank
17th 3.00 Goals Scored 1.55 32nd
26th 3.67 Goals Allowed 3.18 18th
18th 26.8 Shots 21.5 30th
8th 25.7 Shots Allowed 32.3 31st
31st 9.09% Power Play % 12.90% 27th
30th 64.52% Penalty Kill % 84.62% 8th

Flyers vs. Sabres Game Time and TV Channel

  • When: Wednesday, October 21, 2026 at 7:30 p.m. ET
  • TV Channel: TNT
  • Live Stream: Watch this match on HBO Max (Regional restrictions may apply)
  • Where: KeyBank Center in Buffalo, New York

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