Saquon Barkley Week 17 Preview vs. the Bills

Saquon Barkley has a favorable matchup when his Philadelphia Eagles play the Buffalo Bills in Week 17 (Sunday, 4:25 p.m. ET). The Bills concede 144.3 rushing yards per game, fourth-worst in the NFL.

On 261 carries this year, Barkley has picked up a team-best 1,072 rushing yards (71.5 ypg) and has seven rushing touchdowns. As a receiver, Barkley has also caught 37 passes for 273 yards and two touchdowns.

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Barkley vs. the Bills

• Barkley vs the Bills (since 2021): 1 GP / 107 RUSH YPG / 1 RUSH TD
• Five opposing rushers have put up 100 or more rushing yards in a matchup against the Bills during the 2025 season.
• 18 opposing rushers have scored at least one touchdown on the ground against Buffalo this year.
• The Bills have let six opposing players to record two or more rushing TDs against them this season.
• The 144.3 rushing yards the Bills allow per game makes them the 29th-ranked run defense in the league this year.
• So far this season, the Bills have conceded 24 passing TDs to their opponents, averaging 1.6 per game. That ranks 32nd in league play.

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Barkley Rushing Insights

• Barkley hit the over on his rushing yards total set by sportsbooks in five of his 15 opportunities this season (33.3%).
• The Eagles, who are 17th in NFL play in points scored, have passed 49.8% of the time while running 50.2%.
• He has carried the ball in 261 of his team's 433 total rushing attempts this season (60.3%).
• Barkley has a rushing touchdown in seven games this season, but no games with multiple rushing TDs.
• He has nine total touchdowns this season (22.5% of his team's 40 offensive TDs).
• He has 37 red zone rushing carries (50.0% of his team's rushing attempts inside the red zone).

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Barkley's Recent Performance