49ers vs. Colts Dec. 22 Viewing Options: TV, Live Stream

The Indianapolis Colts (8-6) will have their eyes set on halting their four-game losing streak when they challenge the San Francisco 49ers (10-4) at Lucas Oil Stadium on Monday, December 22, 2025.

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49ers vs. Colts: Dec. 22 Viewing Options

• When: Monday, December 22, 2025 at 8:15 p.m. ET
• Where: Lucas Oil Stadium in Indianapolis, Indiana
• TV: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Listen to the game on 107.5 The Fan

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49ers vs. Colts Insights

• The 49ers have averaged three more points this season (24.6) than the Colts have allowed (21.6).
• The Colts, on average, are scoring 7.1 more points per game this season (28) than the 49ers are allowing (20.9).
• San Francisco's offense has averaged 347.5 yards per game this season, within 4.8 yards of the 342.7 Indianapolis' defense has allowed. SF picks up 5.5 yards per play and Indy gives up 5.5.
• Indianapolis' offense holds a 24.3-yard advantage in yards gained per game versus yards allowed by San Francisco's defense this season (357.9 to 333.6). Indianapolis averages 6.2 yards per play, while San Francisco gives up 5.7.
• The Colts' defense has given up an average of 95.1 yards per game to opposing running games this season. That total is about the same as the rushing output per contest for the 49ers (101.4 yards per game).
• The Colts have averaged 128.9 yards per game on the ground this year, 22.8 more yards than the 49ers have allowed to opposing rushing attacks (106.1).
• This season Indianapolis has forced 18 turnovers, compared to the 19 times San Francisco has turned the ball over.
• This year San Francisco has forced 14 turnovers, compared to the 16 times Indianapolis has turned the ball over.

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49ers' Upcoming Schedule

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Colts' Upcoming Schedule