Tyler William Warren Week 16 Preview vs. the 49ers

Indianapolis Colts receiver Tyler William Warren will be up against a middle-of-the-pack pass defense in Week 16 (Monday at 8:15 p.m. ET), versus the San Francisco 49ers. The 49ers are ranked 22nd in terms of passing yards allowed, at 227.6 per game.

Tyler Warren has 63 receptions (while being targeted 90 times) for 718 yards and four TDs, averaging 51.3 yards per game.

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Warren vs. the 49ers

• Warren vs the 49ers (since 2021): No games
• Three players have racked up 100 or more receiving yards in a game against San Francisco in the 2025 season.
• The 49ers have conceded a TD pass to 24 opposing players this year.
• San Francisco has allowed just one player to grab at least two TD catches against it in a matchup on the season.
• The 227.6 passing yards per game yielded by the 49ers defense makes them the NFL's 22nd-ranked pass defense.
• The 49ers' defense is 25th in the league by giving up 1.8 passing touchdowns per game to opposing offenses (25 total passing TDs).

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Warren Receiving Insights

• In the receiving game, Warren has hit the over on his receiving yards prop bet in 42.9% of his games (six of 14).
• Warren has received 20.2% of his team's 445 passing attempts this season (90 targets).
• He is averaging 8.0 yards per target (48th in NFL play), picking up 718 yards on 90 passes thrown his way.
• Tyler William Warren has four games with a touchdown catch this season (out of 14 played). He hasn't scored multiple touchdowns in any game.
• He has scored five of his team's 44 offensive touchdowns this season (11.4%).
• With 16 red zone targets, Warren has been on the receiving end of 26.2% of his team's 61 red zone pass attempts.

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Warren's Recent Performance