George Kittle Week 16 Preview vs. the Colts

George Kittle has a favorable matchup when his San Francisco 49ers face the Indianapolis Colts in Week 16 (Monday, 8:15 p.m. ET). The Colts allow 247.6 passing yards per game, second-worst in the NFL.

Kittle's 45 grabs (on 54 targets) have netted him 484 yards (53.8 per game) and six TDs so far this year.

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Kittle vs. the Colts

• Kittle vs the Colts (since 2021): 1 GP / 83 REC YPG / 1 REC TD
• Indianapolis has allowed six opposing receivers to pick up 100 or more receiving yards in a game in the 2025 season.
• The Colts have conceded a TD pass to 18 opposing players this year.
• Indianapolis has not given up more than one receiving TD to an opposing player on the season.
• The 247.6 passing yards the Colts concede per game makes them the 31st-ranked pass defense in the league this year.
• Opponents of the Colts have scored 18 touchdowns through the air (1.3 per game). The Colts' defense is ninth in the NFL in that category.

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Kittle Receiving Insights

• In the receiving game, Kittle has hit the over on his receiving yards prop bet in 55.6% of his games (five of nine).
• Kittle has been targeted on 54 of his team's 480 passing attempts this season (11.2% target share).
• He is averaging 9.0 yards per target (24th in league play), averaging 484 yards on 54 passes thrown his way.
• In five of nine games this year, Kittle has a touchdown catch, including one game with multiple TD grabs.
• He has 16.2% of his team's 37 offensive touchdowns this season (six).
• Kittle has been targeted 10 times in the red zone (12.8% of his team's 78 red zone pass attempts).

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Kittle's Recent Performance