Alec Pierce Week 16 Preview vs. the 49ers

Alec Pierce has a decent matchup when his Indianapolis Colts play the San Francisco 49ers in Week 16 (Monday, 8:15 p.m. ET). The 49ers have allowed 227.6 passing yards per game, 22nd in the league.

Pierce has posted a team-best 785 yards (on 39 catches) with two TDs so far this season. He's been targeted 68 times, and is averaging 65.4 yards per game.

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Pierce vs. the 49ers

• Pierce vs the 49ers (since 2021): No games
• San Francisco has given up 100 or more receiving yards to three opposing receivers in the 2025 season.
• The 49ers have surrendered a TD pass to 24 opposing players this year.
• San Francisco has given up two or more TD receptions to only one opposing player on the season.
• The 227.6 passing yards per game yielded by the 49ers defense makes them the NFL's 22nd-ranked pass defense.
• The 49ers have the No. 25 defense in the league in passing TDs allowed, giving up 25 this season (1.8 per game).

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Pierce Receiving Insights

• In the receiving game, Pierce has gone over on his receiving yards prop bet in 83.3% of his games (10 of 12).
• Pierce has received 15.3% of his team's 445 passing attempts this season (68 targets).
• He has been targeted 68 times, averaging 11.5 yards per target (third in NFL).
• Pierce has hauled in two touchdown catches this year in 12 games, one apiece on two occasions.
• He has scored two of his team's 44 offensive touchdowns this season (4.5%).
• Pierce (five red zone targets) has been targeted 8.2% of the time in the red zone (61 total red zone pass attempts on the team).

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Pierce's Recent Performance