Shedeur Sanders has a difficult matchup when his Cleveland Browns play the Buffalo Bills in Week 16 (Sunday, 1 p.m. ET). The Bills concede 169.5 passing yards per game, second-best in the league.
Sanders has totaled 946 passing yards this year (189.2 per game), including five passing TDs and six picks. In the running game, Sanders has contributed 74 rushing yards on 10 carries (and one TD), averaging 14.8 yards per game on the ground.
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Sanders vs. the Bills
- Sanders vs the Bills (since 2021): No games
- Not a single opposing quarterback has posted 300 or more passing yards in an outing against Buffalo this season.
- The Bills have given up one or more passing touchdowns to nine opposing quarterbacks this season.
- Buffalo has allowed five players to throw two or more touchdowns in a matchup in 2025.
- The Bills have allowed at least three TD passes in an outing to only one opposing QB this season.
- The 169.5 passing yards per game given up by the Bills defense makes them the NFL's second-ranked pass defense.
- So far this season, the Bills have allowed 16 passing TDs to their opponents, averaging 1.1 per game. That ranks seventh among NFL teams.
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Sanders Passing Insights
- Sanders has exceeded his passing yards prop total in three of four opportunities this year.
- The Browns pass on 58.6% of their plays and run on 41.4%. They are 29th in NFL action in points scored.
- Sanders is averaging 6.9 yards per attempt this season (946 yards on 138 attempts).
- Sanders has thrown for a touchdown in three of five games this season, with more than one TD pass once.
- He has scored six of his team's 23 offensive touchdowns this season (26.1%).
- Sanders accounts for 8.2% of his team's red zone plays, with eight of his total 138 passing attempts inside the opponent's 20-yard line.
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Sanders' Recent Performance
| Opponent | Date | Week | Passing Stats | Rushing Stats |
|---|---|---|---|---|
| vs. Bears | 12/14/2025 | Week 15 | 18-for-35 / 177 YDS / 0 TDs / 3 INTs | 2 ATT / 24 YDS / 0 TDs |
| vs. Titans | 12/7/2025 | Week 14 | 23-for-42 / 364 YDS / 3 TDs / 1 INT | 3 ATT / 29 YDS / 1 TD |
| vs. 49ers | 11/30/2025 | Week 13 | 16-for-25 / 149 YDS / 1 TD / 0 INTs | 1 ATT / 6 YDS / 0 TDs |
| vs. Raiders | 11/23/2025 | Week 12 | 11-for-20 / 209 YDS / 1 TD / 1 INT | 1 ATT / -1 YDS / 0 TDs |
| vs. Ravens | 11/16/2025 | Week 11 | 4-for-16 / 47 YDS / 0 TDs / 1 INT | 3 ATT / 16 YDS / 0 TDs |