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The Jacksonville Jaguars should win their game against the Arizona Cardinals at 4:05 p.m. ET on Sunday, Nov. 23, according to our computer model. If you're seeking additional projections on the final score, spread, and point total, we list those numbers below.
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Jaguars vs. Cardinals Game Info and TV Channel
- When: Sunday, November 23, 2025 at 4:05 p.m. ET
- Where: State Farm Stadium in Glendale, Arizona
- TV: CBS
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
- Live Stream: Watch this game on Paramount+ (Regional restrictions may apply)
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Jaguars vs. Cardinals Odds and Betting Info
- Spread favorite: Jaguars (-2.5)
- Moneyline: Jaguars (-155), Cardinals (+130)
- Total: 47.5 points
Jaguars vs. Cardinals Prediction
- Pick ATS: Jaguars (-2.5)
- Pick OU: Under (47.5)
Prediction:
Jaguars 27 - Cardinals 21
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Jaguars vs. Cardinals Betting Insights
- The Jaguars have won five games against the spread this season, while failing to cover five times.
- The Cardinals have put together a 5-5-0 record against the spread this year.
- Jacksonville has won their only game this season when playing as at least 2.5-point favorites.
- Arizona is 3-2 ATS this season when playing as at least 2.5-point underdogs.
- In the Jaguars' 10 games this season, the combined scoring has gone over the point total five times.
- Cardinals games have hit the over six out of 10 times this year.
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