Photo: Boris Streubel / Getty Images Sport / Getty Images
Which team is going to come out on top on Sunday, Nov. 23, when the Indianapolis Colts and Kansas City Chiefs go head to head at 1 p.m. ET? Our projection system sides with the Colts. Check out our other predictions below, where we break down the final score, spread, and over/under.
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Chiefs vs. Colts Game Info and TV Channel
- When: Sunday, November 23, 2025 at 1 p.m. ET
- Where: GEHA Field at Arrowhead Stadium in Kansas City, Missouri
- TV: CBS
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
- Live Stream: Watch this game on Paramount+ (Regional restrictions may apply)
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Listen to the game on 96.5 The Fan
Chiefs vs. Colts Odds and Betting Info
- Spread favorite: Chiefs (-3.5)
- Moneyline: Chiefs (-186), Colts (+155)
- Total: 50 points
Chiefs vs. Colts Prediction
- Pick ATS: Colts (+3.5)
- Pick OU: Under (50)
Prediction:
Colts 25 - Chiefs 24
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Chiefs vs. Colts Betting Insights
- The Chiefs have put together a 5-5-0 record against the spread this season.
- The Colts have won six games against the spread this season, failing to cover four times.
- Kansas City has been favored by 3.5 points or more five times this season, and covered the spread in three of those matchups.
- Indianapolis has not covered the spread this year (0-1 ATS) when playing as at least 3.5-point underdogs.
- The Chiefs and their opponent have combined to hit the over three out of 10 times this season.
- In the Colts' 10 contests this year, the combined scoring has gone over the point total six times.
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