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SEC opponents match up when the No. 8 Oklahoma Sooners (8-2) and the No. 23 Missouri Tigers (7-3) play on Saturday, November 22, 2025 at Gaylord Family Oklahoma Memorial Stadium.
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Oklahoma vs. Missouri Matchup Info
- Game date: Saturday, November 22, 2025
- Game time: 12 p.m. ET
- Location: Norman, Oklahoma
- Venue: Gaylord Family Oklahoma Memorial Stadium
- TV channel: ABC
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Oklahoma vs. Missouri Odds and Prediction
- Spread favorite: Sooners (-7)
- Moneyline: Sooners (-271), Tigers (+222)
- Total: 42.5 points
- Pick ATS: Oklahoma (-7)
- Pick OU: Over (42.5)
- Prediction: Oklahoma 30, Missouri 18
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Oklahoma vs. Missouri Betting Records and Insights
- Oklahoma is 6-4-0 ATS this season.
- Missouri has compiled a 6-4-0 record against the spread this year.
- The Sooners have been favored by 7 points or more three times this season, and covered the spread in one of those contests.
- This season, games featuring the Oklahoma have hit the over just twice.
- Missouri games have hit the over six out of 10 times this season.