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The No. 22 Louisville Cardinals (2-1) visit the Clemson Tigers (3-1) in ACC play at Littlejohn Coliseum, tipping off at 3 p.m. ET on Sunday, November 16, 2025.
Louisville is a slim 1.5-point favorite against Clemson when the Cardinals hit the court against the Tigers on Sunday. A 127.5-point total has been set for the matchup.
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Louisville vs. Clemson Odds and Game Info
- Game day: Sunday, November 16, 2025
- Game time: 3 p.m. ET
- TV channel: ESPN2
- Location: Clemson, South Carolina
- Arena: Littlejohn Coliseum
- Live stream: Watch this game on Fubo (Regional restrictions may apply)
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Louisville vs. Clemson Odds and Prediction
- Spread favorite: Louisville (-1.5)
- Moneyline: Louisville (-122), Clemson (+102)
- Total: 127.5 points
Pick ATS:Louisville (-1.5)
- Pick OU: Over (127.5)
- Prediction: Louisville 68, Clemson 62
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Louisville vs. Clemson Comparison (2024-25 Stats)
| Louisville Rank | Louisville Stat | Clemson Stat | Clemson Rank | |
|---|---|---|---|---|
| 75th | 71.8 | Points Scored | 66.0 | 158th |
| 248th | 67.5 | Points Allowed | 64.0 | 164th |
| 87th | 14.5 | Assists | 14.9 | 70th |
| 147th | 14.8 | Turnovers | 12.8 | 48th |
| 109th | 42.6% | Field Goal % | 43.0% | 95th |
| 351st | 44.6% | Field Goal % Allowed | 41.8% | 245th |
Louisville 2024-25 Key Players
- Jayda Curry put up 14.4 points per game last season to go with 3.3 assists.
- Olivia Cochran pulled down 6.7 boards per game while also scoring 10.4 points a contest.
- Curry hit an average of 2.1 shots per game from beyond the arc a season ago.
- Tajianna Roberts and Cochran were defensive standouts last season, with Roberts averaging 1.7 steals per game and Cochran collecting 0.4 blocks per contest.
Clemson 2024-25 Key Players
- Loyal McQueen put up 13.5 points per game last season to go with 5.0 assists.
- Tessa Miller averaged 5.9 boards per game in addition to a PPG average of 7.7.
- Hannah Kohn knocked down 2.5 threes per game a season ago.
- Mia Moore averaged 1.5 takeaways per game, while Anya Poole compiled 1.2 rejections per contest.
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