The Clemson Tigers (3-4) meet a fellow ACC foe when they host the Duke Blue Devils (4-3) on Saturday, November 1, 2025 at Memorial Stadium (Clemson, SC).
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Clemson vs. Duke Matchup Info
- Game date: Saturday, November 1, 2025
- Game time: 12 p.m. ET
- Location: Clemson, South Carolina
- Venue: Memorial Stadium (Clemson, SC)
- TV channel: ACC Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Clemson vs. Duke Odds and Prediction
- Spread favorite: Tigers (-3.5)
- Moneyline: Tigers (-166), Blue Devils (+140)
- Total: 54.5 points
- Pick ATS: Duke (+3.5)
- Pick OU: Under (54.5)
- Prediction: Duke 28, Clemson 25
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Clemson vs. Duke Betting Records and Insights
- Clemson has won two games against the spread this season.
- Duke has put together a 3-4-0 record against the spread this year.
- The Tigers have been favored by 3.5 points or more six times this season, and covered the spread in two of those games.
- A total of three out of seven Clemson games this season have gone over the point total.
- Duke games have gone over the point total five out of seven times this season.