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The Houston Texans should win their game against the San Francisco 49ers at 1 p.m. ET on Sunday, Oct. 26, according to our computer model. If you're seeking additional projections on the final score, spread, and point total, we list those numbers below.
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Texans vs. 49ers Game Info and TV Channel
- When: Sunday, October 26, 2025 at 1 p.m. ET
- Where: NRG Stadium in Houston, Texas
- TV: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Listen to the game on SportsRadio 610
Texans vs. 49ers Odds and Betting Info
- Spread favorite: Texans (-2)
- Moneyline: Texans (-131), 49ers (+110)
- Total: 42 points
Texans vs. 49ers Prediction
- Pick ATS: Texans (-2)
- Pick OU: Under (42)
Prediction:
Texans 21 - 49ers 18
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Texans vs. 49ers Betting Insights
- The Texans have a record of 2-4-0 against the spread this season.
- The 49ers have covered four times in seven chances against the spread this year.
- Houston has covered the spread twice this season (2-1 ATS) when playing as at least 2-point favorites.
- San Francisco has covered the spread once when an underdog by 2 points or more this year (in two opportunities).
- So far this season, two Texans games have hit the over.
- 49ers games have gone over the point total four out of seven times this season.
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