Timberwolves vs. Trail Blazers Predictions, Odds & Stats – Oct. 22

Golden State Warriors v Portland Trail Blazers

Photo: Alika Jenner / Getty Images Sport / Getty Images

In the 2025-26 season opener for both teams, the Minnesota Timberwolves are favored by 4.5 points against the Portland Trail Blazers on Wednesday, October 22, 2025 at 10 p.m. ET. The matchup airs on KUNP and FDSN.

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Listen to the game on Rip City Radio 620 Portland

Timberwolves vs. Trail Blazers Predictions for Wednesday

Our computer projections model for this contest calls for a final result of Timberwolves 115, Trail Blazers 109.

  • Moneyline Pick: Timberwolves (-185)
  • Total Pick: Over 221.5 (computer predicts 223.5 points)
  • Pick ATS: Timberwolves (-4.5)

Recent Timberwolves vs. Trail Blazers Matchups

Timberwolves vs Trail Blazers (Recent Matchups)
Date Favorite Spread Total Favorite Moneyline Underdog Moneyline Result
2/8/2025 Timberwolves -3.5 212.5 -163 +137 114-98 MIN
11/13/2024 Timberwolves -10 220 -510 +383 106-98 POR
11/12/2024 Timberwolves -9.5 221.5 -424 +326 122-108 POR
11/8/2024 Timberwolves -12 219.5 -735 +513 127-102 MIN

Timberwolves 2024-25 Betting Trends

  • Minnesota's record against the spread last year was 39-43-0.
  • As 4.5-point favorites or more, the Timberwolves went 19-22 against the spread last season.
  • There were 44 Minnesota games (out of 82) that hit the over last season.
  • The Timberwolves were favored on the moneyline 63 total times last season. They finished 40-23 in those games.
  • When playing as a moneyline favorite with odds of -185 or shorter last year, Minnesota had a record of 28-13 (68.3%).

Trail Blazers 2024-25 Betting Trends

  • Portland won 46 games against the spread last year, while failing to cover 36 times.
  • As 4.5-point underdogs or more, the Trail Blazers went 29-24 against the spread last season.
  • In Portland's games last season, the combined scoring went over the point total 40 times.
  • The Trail Blazers won 26, or 37.7%, of the 69 games they played as underdogs last season.
  • Portland had a record of 18-35, a 34% win rate, when it was set as the underdog by +154 or more by sportsbooks last season.

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Timberwolves vs. Trail Blazers Injury Report

Timberwolves

Timberwolves:

Leonard Miller: Out (Finger)

Trail Blazers

Trail Blazers:

Scoot Henderson: Out (Hamstring),

Damian Lillard: Out For Season (Achilles)

Timberwolves vs. Trail Blazers Game Time and TV Channel

  • Game day: Wednesday, October 22, 2025
  • Game time: 10 p.m. ET
  • TV channel: KUNP and FDSN
  • Location: Portland, Oregon
  • Arena: Moda Center
  • Live stream: Watch this game on Fubo (Regional restrictions may apply)

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