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The Philadelphia 76ers are just 2.5-point underdogs against the Boston Celtics in the season opener for both teams at TD Garden on Wednesday, October 22, 2025. The game tips at 7:30 p.m. ET on NBCS-BOS and NBCS-PH.
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Celtics vs. 76ers Predictions for Wednesday
Our computer model for this matchup predicts a final result of Celtics 122, 76ers 101.
- Moneyline Pick: Celtics (-143)
- Total Pick: Under 227.5 (computer predicts 223.4 points)
- Pick ATS: Celtics (-2.5)
Recent Celtics vs. 76ers Matchups
| Date | Favorite | Spread | Total | Favorite Moneyline | Underdog Moneyline | Result |
|---|---|---|---|---|---|---|
| 3/6/2025 | Celtics | -14 | 217.5 | -962 | +627 | 123-105 BOS |
| 2/20/2025 | Celtics | -7 | 225.5 | -296 | +239 | 124-104 BOS |
| 2/2/2025 | Celtics | -12.5 | 224.5 | -680 | +490 | 118-110 BOS |
| 12/25/2024 | Celtics | -9.5 | 221 | -427 | +330 | 118-114 PHI |
Celtics 2024-25 Betting Trends
- Boston had 39 wins in 82 games against the spread last season.
- The Celtics had an ATS record of 38-39 as 2.5-point favorites or more last year.
- Last season, 37 of Boston's 82 games hit the over.
- The Celtics won 60 of the 78 games they were favored on the moneyline last season (76.9%).
- Boston had a record of 58-17 when it played as a moneyline favorite with odds of -143 or shorter last year (77.3%).
76ers 2024-25 Betting Trends
- Philadelphia covered 29 times in 82 matchups with a spread last season.
- The 76ers' ATS record as underdogs of 2.5 points or more was 21-27 last season.
- In Philadelphia's games last year, the combined scoring went over the point total 48 times.
- The 76ers were underdogs in 53 games last season and won 10 (18.9%) of those contests.
- Philadelphia had a record of 9-38, a 19.1% win rate, when it was set as the underdog by +120 or more by oddsmakers last season.
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Celtics vs. 76ers Injury Report
Celtics
Celtics:
Jayson Tatum: Out (Achilles)
76ers
76ers:
Paul George: Day-To-Day (Knee),
Jared McCain: Out (Thumb)
Celtics vs. 76ers Game Time and TV Channel
- Game day: Wednesday, October 22, 2025
- Game time: 7:30 p.m. ET
- TV channel: NBCS-BOS and NBCS-PH
- Location: Boston, Massachusetts
- Arena: TD Garden
- Live stream: Watch this game on Fubo (Regional restrictions may apply)
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