The Pittsburgh Panthers (4-2) play a conference opponent when they visit the Syracuse Orange (3-3) on Saturday, October 18, 2025 at the JMA Wireless Dome in an ACC clash.
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Pittsburgh vs. Syracuse Matchup Info
- Game date: Saturday, October 18, 2025
- Game time: 7:30 p.m. ET
- Location: Syracuse, New York
- Venue: JMA Wireless Dome
- TV channel: ACC Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Pittsburgh vs. Syracuse Odds and Prediction
- Spread favorite: Panthers (-9.5)
- Moneyline: Panthers (-369), Orange (+289)
- Total: 54.5 points
- Pick ATS: Pittsburgh (-9.5)
- Pick OU: Over (54.5)
- Prediction: Pittsburgh 35, Syracuse 21
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Pittsburgh vs. Syracuse Betting Records and Insights
- Pittsburgh has compiled a 4-2-0 ATS record so far this year.
- Syracuse is 3-2-1 ATS this season.
- The Panthers have won each of their two games this season when playing as at least 9.5-point favorites.
- The Orange have been an underdog by 9.5 points or more three times this season, and covered the spread in two of those matchups.
- In Pittsburgh's six games this season, the combined scoring has gone over the point total four times.
- In 2025, three Syracuse games have gone over the point total.