Northwestern vs. Purdue Football Prediction & Odds - Oct. 18

The Northwestern Wildcats (4-2) and the Purdue Boilermakers (2-4) play on Saturday, October 18, 2025 at Northwestern Medicine Field at Martin Stadium in a battle of Big Ten opponents.

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Northwestern vs. Purdue Matchup Info

  • Game date: Saturday, October 18, 2025
  • Game time: 3 p.m. ET
  • Location: Evanston, Illinois
  • Venue: Northwestern Medicine Field at Martin Stadium
  • TV channel: BTN
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Northwestern vs. Purdue Odds and Prediction

  • Spread favorite: Wildcats (-3.5)
  • Moneyline: Wildcats (-157), Boilermakers (+131)
  • Total: 46.5 points
  • Pick ATS: Northwestern (-3.5)
  • Pick OU: Over (46.5)
  • Prediction: Northwestern 26, Purdue 22

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Northwestern vs. Purdue Betting Records and Insights

  • Northwestern has compiled a 4-2-0 record against the spread this season.
  • Purdue has covered three times in six games with a spread this year.
  • The Wildcats have been favored by 3.5 points or more three times this season, and covered the spread in two of those matchups.
  • The Boilermakers have covered the spread twice when an underdog by 3.5 points or more this year (in four opportunities).
  • So far this season, two Northwestern games have hit the over.
  • Purdue games have hit the over twice this year.