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The No. 3 Indiana Hoosiers (6-0) face a fellow Big Ten foe when they host the Michigan State Spartans (3-3) on Saturday, October 18, 2025 at Memorial Stadium (Bloomington, IN).
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Indiana vs. Michigan State Matchup Info
- Game date: Saturday, October 18, 2025
- Game time: 3:30 p.m. ET
- Location: Bloomington, Indiana
- Venue: Memorial Stadium (Bloomington, IN)
- TV channel: Peacock
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Indiana vs. Michigan State Odds and Prediction
- Spread favorite: Hoosiers (-27.5)
- Moneyline: Hoosiers (-5556), Spartans (+1720)
- Total: 49.5 points
- Pick ATS: Indiana (-27.5)
- Pick OU: Over (49.5)
- Prediction: Indiana 49, Michigan State 7
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Indiana vs. Michigan State Betting Records and Insights
- Indiana has won four games against the spread this season, while failing to cover twice.
- Michigan State has won two games against the spread this season.
- The Hoosiers have won each of their two games this season when playing as at least 27.5-point favorites.
- Indiana and its opponent have combined to go over the point total three out of six times this season.
- In 2025, four Michigan State games have gone over the point total.