
The Clemson Tigers (3-3) take on a fellow ACC opponent when they host the SMU Mustangs (4-2) on Saturday, October 18, 2025 at Memorial Stadium (Clemson, SC).
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Clemson vs. SMU Matchup Info
- Game date: Saturday, October 18, 2025
- Game time: 3:30 p.m. ET
- Location: Clemson, South Carolina
- Venue: Memorial Stadium (Clemson, SC)
- TV channel: ACC Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Clemson vs. SMU Odds and Prediction
- Spread favorite: Tigers (-3.5)
- Moneyline: Tigers (-175), Mustangs (+147)
- Total: 50.5 points
- Pick ATS: SMU (+3.5)
- Pick OU: Over (50.5)
- Prediction: Clemson 27, SMU 24
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Clemson vs. SMU Betting Records and Insights
- Clemson has a record of 2-4-0 against the spread this season.
- SMU has won just one game against the spread this year.
- The Tigers have been favored by 3.5 points or more five times this season, and covered the spread in two of those contests.
- The Mustangs have not covered the spread this year (0-1 ATS) when playing as at least 3.5-point underdogs.
- So far this season, two Clemson games have hit the over.
- So far this season, just one SMU game has hit the over.