Illinois vs. Purdue Football Prediction & Odds - Oct. 4

The No. 22 Illinois Fighting Illini (4-1) and the Purdue Boilermakers (2-2) square off on Saturday, October 4, 2025 at Ross-Ade Stadium in a battle of Big Ten opponents.

Watch college football live without cable. Stream ACC, SEC, ESPN and more with Fubo. What is Fubo? Fubo is a streaming service that gives you access to your favorite live sports and shows on demand. Sign up today and start watching college football games now.

Illinois vs. Purdue Matchup Info

  • Game date: Saturday, October 4, 2025
  • Game time: 12 p.m. ET
  • Location: West Lafayette, Indiana
  • Venue: Ross-Ade Stadium
  • TV channel: BTN
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Stop missing games and start streaming college football right now on Fubo.

Illinois vs. Purdue Odds and Prediction

  • Spread favorite: Fighting Illini (-8.5)
  • Moneyline: Fighting Illini (-333), Boilermakers (+264)
  • Total: 55 points
  • Pick ATS: Illinois (-8.5)
  • Pick OU: Over (55)
  • Prediction: Illinois 36, Purdue 22

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

Looking for officially licensed gear? Fanatics has jerseys, hats, apparel, memorabilia, trading cards, collectibles and more.

Illinois vs. Purdue Betting Records and Insights

  • Illinois has compiled a 4-1-0 record against the spread this season.
  • Purdue has a record of 2-2-0 against the spread this year.
  • The Fighting Illini have covered the spread when playing as at least 8.5-point favorites in two of two games this season.
  • The Boilermakers have covered the spread once this year (1-1 ATS) when playing as at least 8.5-point underdogs.
  • In Illinois' five games this season, the combined scoring has gone over the point total three times.
  • So far this year, just one Purdue game has hit the over.