Which team is going to come out on top on Thursday, Oct. 2, when the Los Angeles Rams and San Francisco 49ers square off at 8:15 p.m. ET? Our computer projection believes in the Rams. Dive into our other predictions below, where we break down the final score, spread, and over/under.
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Rams vs. 49ers Game Info and TV Channel
- When: Thursday, October 2, 2025 at 8:15 p.m. ET
- Where: SoFi Stadium in Inglewood, California
- TV: Amazon Prime Video
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
- Live Stream: Watch this game on Prime Video (Regional restrictions may apply)
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Listen to the game on 93.1 Jack FM
Rams vs. 49ers Odds and Betting Info
- Spread favorite: Rams (-8.5)
- Moneyline: Rams (-467), 49ers (+359)
- Total: 44.5 points
Rams vs. 49ers Prediction
- Pick ATS: 49ers (+8.5)
- Pick OU: Under (44.5)
Prediction:
Rams 23 - 49ers 19
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Rams vs. 49ers Betting Insights
- The Rams have won three games against the spread this season, while failing to cover once.
- The 49ers have won two games against the spread this season.
- Rams games have hit the over twice this season.
- So far this year, two 49ers games have gone over the point total.
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