Christian McCaffrey Week 5 Preview vs. the Rams

Christian McCaffrey will be up against the 10th-best rushing defense in the NFL when his San Francisco 49ers take on the Los Angeles Rams in Week 5, on Thursday at 8:15 p.m. ET.

In the running game, McCaffrey has put up a team-leading 225 rushing yards (56.3 ypg) on 69 attempts. McCaffrey has also reeled in 31 passes for 305 yards (76.3 ypg). McCaffrey's also scored two TDs through the air attack.

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McCaffrey vs. the Rams

• McCaffrey vs the Rams (since 2021): 1 GP / 128 RUSH YPG / 2 RUSH TD
• The Rams defense has not allowed a rusher to pick up 100 or more yards on the ground in a game in the 2025 season.
• Los Angeles has allowed one or more rushing TDs to two opposing players this year.
• The Rams have not allowed any opposing players to record two or more rushing TDs against them this season.
• The Rams give up 98.5 rushing yards per game, the NFL's 10th-ranked rush defense this season.
• The Rams have the No. 3 defense in the league in rushing touchdowns allowed, conceding two this season (0.5 per game).

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McCaffrey Rushing Insights

• McCaffrey has exceeded the rushing yards prop bet total set for him one time in four opportunities this season.
• The 49ers pass on 59.1% of their plays and run on 40.9%. They are 23rd in NFL play in points scored.
• His team has attempted 106 rushes this season. He's handled 69 of those carries (65.1%).
• McCaffrey has no rushing touchdowns in four games this year.
• He has two total touchdowns this season (25.0% of his team's eight offensive TDs).
• He has 16 carries in the red zone (76.2% of his team's 21 red zone rushes).

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McCaffrey's Recent Performance