Photo: Johnnie Izquierdo / Getty Images Sport / Getty Images
Which team is going to emerge victorious on Sunday, Sept. 28, when the Los Angeles Rams and Indianapolis Colts square off at 4:05 p.m. ET? Our projection model sides with the Rams. Dive into our other predictions below, where we break down the final score, spread, and over/under.
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Rams vs. Colts Game Info and TV Channel
- When: Sunday, September 28, 2025 at 4:05 p.m. ET
- Where: SoFi Stadium in Inglewood, California
- TV: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Listen to the game on 93.1 Jack FM
Rams vs. Colts Odds and Betting Info
- Spread favorite: Rams (-3.5)
- Moneyline: Rams (-189), Colts (+157)
- Total: 49.5 points
Rams vs. Colts Prediction
- Pick ATS: Rams (-3.5)
- Pick OU: Under (49.5)
Prediction:
Rams 29 - Colts 17
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Rams vs. Colts Betting Insights
- The Rams have covered twice in three games with a spread this season.
- The Colts have put together a 3-0-0 ATS record so far this season.
- Los Angeles has won their only game this season when playing as at least 3.5-point favorites.
- This season, games featuring the Rams have gone over the point total twice.
- Colts games have hit the over twice this season.
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