The Louisville Cardinals (3-0) hit the road for an ACC battle against the Pittsburgh Panthers (2-1) on Saturday, September 27, 2025 at Acrisure Stadium.
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Louisville vs. Pittsburgh Matchup Info
- Game date: Saturday, September 27, 2025
- Game time: 12 p.m. ET
- Location: Pittsburgh, Pennsylvania
- Venue: Acrisure Stadium
- TV channel: ESPN2
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Louisville vs. Pittsburgh Odds and Prediction
- Spread favorite: Cardinals (-3.5)
- Moneyline: Cardinals (-174), Panthers (+144)
- Total: 56.5 points
- Pick ATS: Louisville (-3.5)
- Pick OU: Under (56.5)
- Prediction: Louisville 30, Pittsburgh 24
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Louisville vs. Pittsburgh Betting Records and Insights
- Louisville has not won against the spread this season in three chances.
- Pittsburgh has won two games against the spread this season.
- The Cardinals have not covered the spread this season (0-3 ATS) when playing as at least 3.5-point favorites.
- Louisville games have hit the over twice this season.
- This year, games featuring Pittsburgh have gone over the point total twice.