49ers vs. Rams Week 3 Predictions, Odds and Stats

In the game between the San Francisco 49ers and Los Angeles Rams on Sunday, Sept. 22 at 4:25 p.m. ET, our projection system expects the 49ers to come away with the victory. Wanting projections on the final score, spread, and point total, too? Find a full game projection below.

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49ers vs. Rams Game Info and TV Channel

When: Sunday, September 22, 2024 at 4:25 p.m. ETWhere: SoFi Stadium in Inglewood, CaliforniaTV: FOXLive Stream: Watch this game on Fubo (Regional restrictions may apply)Catch every NFL touchdown with NFL RedZone on Fubo.

49ers vs. Rams Odds and Betting Info

Spread favorite: 49ers (-6.5)Moneyline: 49ers (-287), Rams (+233)Total: 44.5 points

49ers vs. Rams Prediction

Pick ATS: Rams (+6.5)

Pick OU: Over (44.5)

Prediction:

49ers 25 - Rams 22

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49ers vs. Rams Betting Insights

The 49ers have covered once in two games with a spread this season.The Rams have compiled a 0-2-0 record against the spread this season.So far this season, one of the 49ers games has hit the over.Rams games have gone over the point total once this year.Looking for NFL tickets? Head to StubHub today and see your team live.