Patriots vs. Saints Week 6 Predictions, Odds and Stats

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Our computer model predicts the New England Patriots will beat the New Orleans Saints on Sunday, Oct. 12 at 1 p.m. ET. For a complete projection on the game at Caesars Superdome, which includes our prediction on the spread, over/under, and final score, keep reading.

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Patriots vs. Saints Game Info and TV Channel

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Listen to the game on WWL

Patriots vs. Saints Odds and Betting Info

  • Spread favorite: Patriots (-3.5)
  • Moneyline: Patriots (-192), Saints (+160)
  • Total: 45.5 points

Patriots vs. Saints Prediction

  • Pick ATS: Patriots (-3.5)
  • Pick OU: Under (45.5)

Prediction:

Patriots 25 - Saints 20

    Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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    Patriots vs. Saints Betting Insights

    • The Patriots have put together a 3-2-0 record against the spread this season.
    • The Saints have covered twice in five matchups with a spread this year.
    • New England has covered the spread when playing as at least 3.5-point favorites in their only opportunity this season.
    • New Orleans has been an underdog by 3.5 points or more three times this season, and covered the spread in one of those games.
    • So far this season, two Patriots games have hit the over.
    • In 2025, three Saints games have gone over the point total.

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