The No. 22 Iowa State Cyclones (5-1) hit the road for a Big 12 battle against the Colorado Buffaloes (2-4) on Saturday, October 11, 2025 at Folsom Field.
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Iowa State vs. Colorado Matchup Info
- Game date: Saturday, October 11, 2025
- Game time: 3:30 p.m. ET
- Location: Boulder, Colorado
- Venue: Folsom Field
- TV channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Iowa State vs. Colorado Odds and Prediction
- Spread favorite: Cyclones (-2.5)
- Moneyline: Cyclones (-139), Buffaloes (+118)
- Total: 52 points
- Pick ATS: Iowa State (-2.5)
- Pick OU: Under (52)
- Prediction: Iowa State 29, Colorado 20
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Iowa State vs. Colorado Betting Records and Insights
- Iowa State has covered three times in six chances against the spread this season.
- Colorado has won three games against the spread this year, failing to cover three times.
- The Cyclones have covered the spread twice when favored by 2.5 points or more this season (in four opportunities).
- The Buffaloes have covered the spread once this season (1-3 ATS) when playing as at least 2.5-point underdogs.
- In Iowa State's six games this season, the combined scoring has gone over the point total three times.
- This season, games featuring Colorado have gone over the point total twice.