TCU vs. Colorado Football Prediction & Odds - Oct. 4

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The TCU Horned Frogs (3-1) host a Big 12 battle against the Colorado Buffaloes (2-3) on Saturday, October 4, 2025 at Amon G. Carter Stadium.

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TCU vs. Colorado Matchup Info

  • Game date: Saturday, October 4, 2025
  • Game time: 7:30 p.m. ET
  • Location: Fort Worth, Texas
  • Venue: Amon G. Carter Stadium
  • TV channel: FOX
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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TCU vs. Colorado Odds and Prediction

  • Spread favorite: Horned Frogs (-13.5)
  • Moneyline: Horned Frogs (-549), Buffaloes (+405)
  • Total: 57.5 points
  • Pick ATS: Colorado (+13.5)
  • Pick OU: Under (57.5)
  • Prediction: TCU 31, Colorado 22

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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TCU vs. Colorado Betting Records and Insights

  • TCU has a record of 2-1-1 against the spread this season.
  • Colorado has won three games against the spread this year, failing to cover twice.
  • The Horned Frogs have been favored by 13.5 points or more this season once, and failed to cover the spread.
  • So far this season, two TCU games have hit the over.
  • Colorado games have gone over the point total twice this season.