Clemson vs. UNC Football Prediction & Odds - Oct. 4

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The Clemson Tigers (1-3) hit the road for an ACC battle against the North Carolina Tar Heels (2-2) on Saturday, October 4, 2025 at Kenan Stadium.

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Clemson vs. North Carolina Matchup Info

  • Game date: Saturday, October 4, 2025
  • Game time: 12 p.m. ET
  • Location: Chapel Hill, North Carolina
  • Venue: Kenan Stadium
  • TV channel: ESPN
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Clemson vs. North Carolina Odds and Prediction

  • Spread favorite: Tigers (-14.5)
  • Moneyline: Tigers (-613), Tar Heels (+446)
  • Total: 46.5 points
  • Pick ATS: Clemson (-14.5)
  • Pick OU: Under (46.5)
  • Prediction: Clemson 31, North Carolina 12

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Clemson vs. North Carolina Betting Records and Insights

  • Clemson has put together a 0-4-0 record against the spread this season.
  • North Carolina has covered twice in four games with a spread this year.
  • The Tigers have been favored by 14.5 points or more this season twice, and failed to cover both times.
  • Clemson games have gone over the point total just once this season.
  • Games featuring North Carolina have gone over the point total just once this season.