Cincy vs. Iowa St Football Prediction & Odds - Oct. 4

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The Cincinnati Bearcats (3-1) host a Big 12 battle against the No. 14 Iowa State Cyclones (5-0) on Saturday, October 4, 2025 at Nippert Stadium.

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Cincinnati vs. Iowa State Matchup Info

  • Game date: Saturday, October 4, 2025
  • Game time: 12 p.m. ET
  • Location: Cincinnati, Ohio
  • Venue: Nippert Stadium
  • TV channel: ESPN2
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Cincinnati vs. Iowa State Odds and Prediction

  • Spread favorite: Bearcats (-1.5)
  • Moneyline: Bearcats (-122), Cyclones (+102)
  • Total: 55.5 points
  • Pick ATS: Iowa State (+1.5)
  • Pick OU: Under (55.5)
  • Prediction: Iowa State 25, Cincinnati 24

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Cincinnati vs. Iowa State Betting Records and Insights

  • Cincinnati has compiled a 3-1-0 ATS record so far this year.
  • Iowa State is 3-1-1 ATS this year.
  • The Bearcats have covered the spread once when favored by 1.5 points or more this season (in two opportunities).
  • The Cyclones have been an underdog by 1.5 points or more once this season, and covered the spread.
  • Cincinnati games have gone over the point total three out of four times this season.
  • Iowa State games have hit the over twice this season.