Kyren Williams Week 5 Preview vs. the 49ers

Los Angeles Rams running back Kyren Williams will face a mediocre run defense in Week 5 (Thursday at 8:15 p.m. ET), up against the San Francisco 49ers. The 49ers are ranked 17th in terms of rushing yards conceded, at 115.5 per game.

On 68 carries this year, Williams has rushed for a team-leading 303 yards (75.8 ypg). He has scored one TD on the ground. As a pass-catcher, Williams has tallied eight catches for 52 yards (13.0 ypg) and one touchdown.

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Williams vs. the 49ers

• Williams vs the 49ers (since 2021): 2 GP / 98.5 RUSH YPG / 2 RUSH TD
• One opposing rusher has racked up 100 or more rushing yards in a matchup against the 49ers during the 2025 season.
• Two opposing rushers have scored at least one touchdown on the ground against San Francisco this year.
• The 49ers have not given up two or more rushing TDs to an opposing player this season.
• The 115.5 rushing yards per game allowed by the 49ers defense makes them the NFL's 17th-ranked run defense.
• Opponents of the 49ers have put up two touchdowns on the ground (0.5 per game). The 49ers' defense is third in the NFL in that category.

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Williams Rushing Insights

• Williams has exceeded the rushing yards prop bet total set for him twice in four opportunities this season.
• The Rams, who are 13th in NFL play in points scored, have passed 56.1% of the time while running 43.9%.
• He has carried the ball in 68 of his team's 107 total rushing attempts this season (63.6%).
• Williams has rushed for a touchdown once this season in four games played.
• He has scored two of his team's 11 offensive touchdowns this season (18.2%).
• He has 10 red zone rushing carries (55.6% of his team's rushing attempts inside the red zone).

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Williams' Recent Performance