UConn vs. Buffalo Football Prediction & Odds - Sept. 27

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The UConn Huskies (2-2) hit the road to square off against the Buffalo Bulls (2-2) at UB Stadium on Saturday, September 27, 2025.

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UConn vs. Buffalo Matchup Info

  • Game date: Saturday, September 27, 2025
  • Game time: 3:30 p.m. ET
  • Location: Buffalo, New York
  • Venue: UB Stadium
  • TV channel: ESPN+
  • Live Stream: Watch this game on ESPN+

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UConn vs. Buffalo Odds and Prediction

  • Spread favorite: Huskies (-3)
  • Moneyline: Huskies (-156), Bulls (+131)
  • Total: 51 points
  • Pick ATS: UConn (-3)
  • Pick OU: Over (51)
  • Prediction: UConn 30, Buffalo 23

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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UConn vs. Buffalo Betting Records and Insights

  • UConn has covered once in four matchups with a spread this season.
  • Buffalo has covered twice in four matchups with a spread this season.
  • The Huskies have covered the spread once when favored by 3 points or more this season (in three opportunities).
  • The Bulls have won their only game this season when playing as at least 3-point underdogs.
  • A total of three out of four UConn games this season have hit the over.
  • Buffalo games have gone over the point total twice this season.

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