James Cook Week 4 Preview vs. the Saints

Buffalo Bills running back James Cook will face a mediocre run defense in Week 4 (Sunday at 1 p.m. ET), up against the New Orleans Saints. The Saints are ranked 14th in terms of rushing yards allowed, at 103.3 per game.

Cook, as part of the rushing attack, leads the team with 284 rushing yards (94.7 ypg) on 53 attempts while scoring four rushing TDs. Cook has tacked on nine receptions for 71 yards, good for 23.7 yards per game.

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Cook vs. the Saints

• Cook vs the Saints (since 2021): No games
• The Saints defense has not allowed a rusher to pile up 100 or more yards on the ground in a game in the 2025 season.
• One opposing rusher has scored at least one touchdown on the ground against New Orleans this year.
• The Saints have allowed two or more rushing TDs to one opposing rusher this season.
• The Saints give up 103.3 yards per game on the ground, the NFL's 14th-ranked run defense this season.
• Opponents of the Saints have put up two touchdowns on the ground (0.7 per game). The Saints' defense is eighth in the league in that category.

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Cook Rushing Insights

• Cook has hit the over on his rushing yards total two times in three opportunities this season.
• The Bills, who are fifth in NFL play in points scored, have passed 50.0% of the time while running 50.0%.
• His team has attempted 101 rushes this season. He's taken 53 of those carries (52.5%).
• Cook has rushing touchdowns in all three games this season, including multiple TDs once.
• He has scored four of his team's 12 offensive touchdowns this season (33.3%).
• He has 12 red zone rushing carries (52.2% of his team's rushing attempts inside the red zone).

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Cook's Recent Performance