Indiana vs. Iowa Football Prediction & Odds - Sept. 27

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The No. 11 Indiana Hoosiers (4-0) and the Iowa Hawkeyes (3-1) play on Saturday, September 27, 2025 at Kinnick Stadium in a battle of Big Ten opponents.

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Indiana vs. Iowa Matchup Info

  • Game date: Saturday, September 27, 2025
  • Game time: 3:30 p.m. ET
  • Location: Iowa City, Iowa
  • Venue: Kinnick Stadium
  • TV channel: Peacock

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Indiana vs. Iowa Odds and Prediction

  • Spread favorite: Hoosiers (-8.5)
  • Moneyline: Hoosiers (-325), Hawkeyes (+258)
  • Total: 47.5 points
  • Pick ATS: Indiana (-8.5)
  • Pick OU: Over (47.5)
  • Prediction: Indiana 48, Iowa 6

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Indiana vs. Iowa Betting Records and Insights

  • Indiana has put together a 3-1-0 ATS record so far this year.
  • Iowa has won two games against the spread this year.
  • The Hoosiers have covered the spread twice when favored by 8.5 points or more this season (in three opportunities).
  • A total of three out of four Indiana games this season have hit the over.
  • This season, games featuring Iowa have gone over the point total twice.