Based on our computer projections, the Los Angeles Chargers will take down the New York Giants when the two teams come together at MetLife Stadium on Sunday, Sept. 28, which begins at 1 p.m. ET. For our projections on the spead, point total, and final score, check out the rest of the article below.
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Chargers vs. Giants Game Info and TV Channel
- When: Sunday, September 28, 2025 at 1 p.m. ET
- Where: MetLife Stadium in East Rutherford, New Jersey
- TV: CBS
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
- Live Stream: Watch this game on Paramount+ (Regional restrictions may apply)
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Listen to the game on WFAN Sports Radio New York
Chargers vs. Giants Odds and Betting Info
- Spread favorite: Chargers (-6.5)
- Moneyline: Chargers (-296), Giants (+238)
- Total: 43.5 points
Chargers vs. Giants Prediction
- Pick ATS: Chargers (-6.5)
- Pick OU: Under (43.5)
Prediction:
Chargers 27 - Giants 14
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Chargers vs. Giants Betting Insights
- The Chargers have covered in each of their three games with a spread this season.
- The Giants have covered once in three games ATS this season.
- New York has been an underdog by 6.5 points or more this season once, and failed to cover the spread.
- So far this season, one of the Chargers games has hit the over.
- Games featuring the Giants have hit the over once this year.
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