Our computer model predicts the San Francisco 49ers will beat the Jacksonville Jaguars on Sunday, Sept. 28 at 4:05 p.m. ET. For a complete projection on the matchup at Levi's Stadium, which includes our prediction on the spread, over/under, and final score, keep reading.
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49ers vs. Jaguars Game Info and TV Channel
- When: Sunday, September 28, 2025 at 4:05 p.m. ET
- Where: Levi's Stadium in Santa Clara, California
- TV: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Listen to the game on 107.7 The Bone
49ers vs. Jaguars Odds and Betting Info
- Spread favorite: 49ers (-3.5)
- Moneyline: 49ers (-185), Jaguars (+152)
- Total: 46.5 points
49ers vs. Jaguars Prediction
- Pick ATS: 49ers (-3.5)
- Pick OU: Over (46.5)
Prediction:
49ers 28 - Jaguars 19
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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49ers vs. Jaguars Betting Insights
- The 49ers have won two games against the spread this season.
- The Jaguars have a record of 2-1-0 against the spread this year.
- Jacksonville has not covered the spread when an underdog by 3.5 points or more this year (in one opportunity).
- 49ers games have hit the over once this season.
- Games featuring the Jaguars have hit the over once this year.
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