The Houston Cougars (2-0) play a conference opponent when they host the Colorado Buffaloes (1-1) on Friday, September 12, 2025 at TDECU Stadium in a Big 12 battle.
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Houston vs. Colorado Matchup Info
- Game date: Friday, September 12, 2025
- Game time: 7:30 p.m. ET
- Location: Houston, Texas
- Venue: TDECU Stadium
- TV channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Houston vs. Colorado Odds and Prediction
- Spread favorite: Cougars (-4.5)
- Moneyline: Cougars (-213), Buffaloes (+176)
- Total: 45 points
- Pick ATS: Colorado (+4.5)
- Pick OU: Under (45)
- Prediction: Houston 23, Colorado 20
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Houston vs. Colorado Betting Records and Insights
- Houston has covered in each of its two games with a spread this season.
- Colorado has covered once in two chances against the spread this year.
- The Cougars have won each of their two games this season when playing as at least 4.5-point favorites.
- So far this season, one Houston game has hit the over.
- Colorado and its opponent have not yet hit the over in 2025.