In the game between the Seattle Seahawks and San Francisco 49ers on Sunday, Sept. 7 at 4:05 p.m. ET, our computer model expects the Seahawks to come away with the victory. Seeking projections on the final score, spread, and point total, too? Find a full game projection below.
Don't miss a touchdown this NFL season. Catch every score with NFL RedZone on Fubo. What is Fubo? Fubo is a streaming service that gives you access to your favorite live sports and shows on demand. Sign up today and watch seven hours of football from every NFL game every Sunday.
49ers vs. Seahawks Game Info and TV Channel
- When: Sunday, September 7, 2025 at 4:05 p.m. ET
- Where: Lumen Field in Seattle, Washington
- TV: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
Catch every NFL touchdown with NFL RedZone on Fubo.
49ers vs. Seahawks Odds and Betting Info
- Spread favorite: 49ers (-1.5)
- Moneyline: 49ers (-120), Seahawks (+100)
- Total: 43.5 points
49ers vs. Seahawks Prediction
- Pick ATS: Seahawks (+1.5)
- Pick OU: Over (43.5)
Prediction:
Seahawks 27 - 49ers 19
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
See how these predictions pan out and sign up for NFL RedZone on Fubo to catch every score on Sundays this fall.
49ers vs. Seahawks Betting Insights (2024 Stats)
- The 49ers covered five times in 17 matchups with a spread last season.
- The Seahawks compiled a 6-10-1 record against the spread last season.
- San Francisco was favored by 1.5 points or more 13 times last season, and covered the spread in five of those contests.
- Seattle had an ATS record of 4-6 when playing as at least 1.5-point underdogs last season.
- 49ers games hit the over 11 out of 17 times last season.
- Last year, nine Seahawks games hit the over.
Looking for NFL tickets? Head to StubHub today and see your team live.