Pitt vs. CMU Football Prediction & Odds - Sept. 6

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The Pittsburgh Panthers (1-0) and the Central Michigan Chippewas (1-0) square off at Acrisure Stadium on Saturday, September 6, 2025.

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Pittsburgh vs. Central Michigan Matchup Info

  • Game date: Saturday, September 6, 2025
  • Game time: 12 p.m. ET
  • Location: Pittsburgh, Pennsylvania
  • Venue: Acrisure Stadium
  • TV channel: ESPNU
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Pittsburgh vs. Central Michigan Odds and Prediction

  • Spread favorite: Panthers (-21.5)
  • Moneyline: Panthers (-2041), Chippewas (+1016)
  • Total: 49.5 points
  • Pick ATS: Pittsburgh (-21.5)
  • Pick OU: Over (49.5)
  • Prediction: Pittsburgh 38, Central Michigan 16

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Pittsburgh vs. Central Michigan Betting Records and Insights

  • Pittsburgh has won one game against the spread this season.
  • Central Michigan has won all one of its games against the spread this season.
  • The Panthers have covered the spread when playing as at least 21.5-point favorites in their only opportunity this season.
  • This season, games featuring Pittsburgh have hit the over every time.
  • Central Michigan and its opponent have not yet hit the over in 2025.