Louisville vs. Creighton Predictions - NCAA Tournament

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The No. 8 seed Louisville Cardinals (27-7) and the No. 9 seed Creighton Bluejays (24-10) will meet in the opening round of the NCAA Tournament on Thursday at 12:15 p.m. ET. The matchup airs on CBS.

Louisville is a moderate 2.5-point favorite against Creighton when the Cardinals play the Bluejays on Thursday. The over/under is 144.5 points for the game.

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Louisville vs. Creighton Odds and Game Info

  • Game day: Thursday, March 20, 2025
  • Game time: 12:15 p.m. ET
  • TV channel: CBS
  • Location: Lexington, Kentucky
  • Arena: Rupp Arena
  • Live stream: Watch this game on Paramount+ (Regional restrictions may apply)

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Louisville vs. Creighton Odds and Prediction

  • Spread favorite: Louisville (-2.5)
  • Moneyline: Louisville (-146), Creighton (+122)
  • Total: 144.5 points

Pick ATS:Louisville (-2.5)

  • Pick OU: Over (144.5)
  • Prediction: Louisville 75, Creighton 71

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Louisville vs. Creighton Comparison

Louisville Rank Louisville Stat Creighton Stat Creighton Rank
68th 78.6 Points Scored 75.2 137th
83rd 68.9 Points Allowed 69.5 97th
143rd 14.0 Assists 17.1 14th
162nd 11.0 Turnovers 11.5 219th
140th 45.4% Field Goal % 47.5% 43rd
95th 42.5% Field Goal % Allowed 41.2% 45th

Louisville Key Players

  • The Cardinals scoring leader is Terrence Edwards, who averages 16.6 per contest to go with 4.1 rebounds and 2.6 assists.
  • J'Vonne Hadley leads Louisville in rebounding, averaging 7.3 per game, while Chucky Hepburn leads the team in assists, distributing an average of 5.8 in each contest.
  • The Cardinals get the most three-point shooting production out of Reyne Smith, who knocks down 3.5 threes per game.
  • The Louisville steals leader is Hepburn, who averages 2.5 takeaways per game, while its blocks leader is James Scott, who compiles 0.9 rejections per contest.

Creighton Key Players

  • Ryan Kalkbrenner sits on top of the Bluejays leaderboards for scoring and rebounding with 19.4 points and 8.8 rebounds per game.
  • Steven Ashworth dishes out more assists than any other Creighton player with 6.8 per game. Ashworth also scores 16.3 points and grabs 4.1 rebounds per game.
  • Ashworth hits 3.1 three-pointers per game, the most on the Bluejays.
  • Creighton's leader in steals is Jamiya Neal with 0.9 per game, and its leader in blocks is Kalkbrenner with 2.7 per game.

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