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Our computer model predicts the Arizona Cardinals will take down the San Francisco 49ers on Sunday, Jan. 5 at 4:25 p.m. ET. For a complete projection on the game at State Farm Stadium, which includes our prediction on the spread, over/under, and final score, keep reading.
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Cardinals vs. 49ers Game Info and TV Channel
- When: Sunday, January 5, 2025 at 4:25 p.m. ET
- Where: State Farm Stadium in Glendale, Arizona
- TV: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Cardinals vs. 49ers Odds and Betting Info
- Spread favorite: Cardinals (-5)
- Moneyline: Cardinals (-217), 49ers (+179)
- Total: 42.5 points
Cardinals vs. 49ers Prediction
- Pick ATS: Cardinals (-5)
- Pick OU: Over (42.5)
Prediction:
Cardinals 26 - 49ers 20
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Cardinals vs. 49ers Betting Insights
- The Cardinals have compiled a 10-6-0 record against the spread this season.
- The 49ers have won five games against the spread this season, failing to cover 11 times.
- Arizona has been favored by 5 points or more two times this season, and covered the spread in one of those matchups.
- San Francisco has been an underdog by 5 points or more this season twice, and failed to cover both times.
- Cardinals games have hit the over seven out of 16 times this season.
- 49ers games have gone over the point total 10 out of 16 times this year.
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