Lions vs. Bills Week 15 Predictions, Odds and Stats

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Our computer model predicts the Detroit Lions will beat the Buffalo Bills on Sunday, Dec. 15 at 4:25 p.m. ET. For a complete projection on the game at Ford Field, which includes our prediction on the spread, over/under, and final score, keep reading.

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Lions vs. Bills Game Info and TV Channel

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Lions vs. Bills Odds and Betting Info

  • Spread favorite: Lions (-2.5)
  • Moneyline: Lions (-143), Bills (+120)
  • Total: 54.5 points

Lions vs. Bills Prediction

  • Pick ATS: Lions (-2.5)
  • Pick OU: Under (54.5)

Prediction:

Lions 30 - Bills 21

    Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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    Lions vs. Bills Betting Insights

    • The Lions are 9-4-0 ATS this season.
    • The Bills have covered eight times in 13 chances against the spread this year.
    • Detroit is 8-4 ATS this season when playing as at least 2.5-point favorites.
    • Buffalo has covered the spread once when an underdog by 2.5 points or more this year (in two opportunities).
    • Lions games have gone over the point total six out of 13 times this season.
    • The Bills and their opponent have combined to hit the over nine out of 13 times this year.

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