49ers vs. Rams Week 15 Predictions, Odds and Stats

Buffalo Bills v Los Angeles Rams

Photo: Getty Images

Which team is going to win on Thursday, Dec. 12, when the San Francisco 49ers and Los Angeles Rams match up at 8:15 p.m. ET? Our projection model sides with the 49ers. Check out our other predictions below, where we break down the final score, spread, and over/under.

Watch Thursday Night Football exclusively on Amazon Prime. Use our link to sign up for Prime Video.

49ers vs. Rams Game Info and TV Channel

  • When: Thursday, December 12, 2024 at 8:15 p.m. ET
  • Where: Levi's Stadium in Santa Clara, California
  • TV: Amazon Prime Video
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)
  • Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Catch every NFL touchdown with NFL RedZone on Fubo.

49ers vs. Rams Odds and Betting Info

  • Spread favorite: 49ers (-2.5)
  • Moneyline: 49ers (-148), Rams (+124)
  • Total: 48.5 points

49ers vs. Rams Prediction

  • Pick ATS: Rams (+2.5)
  • Pick OU: Under (48.5)

Prediction:

49ers 25 - Rams 23

    Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

    See how these predictions pan out and sign up for NFL RedZone on Fubo to catch every score on Sundays this fall.

    49ers vs. Rams Betting Insights

    • The 49ers are 5-8-0 ATS this season.
    • The Rams have put together a 6-7-0 record against the spread this year.
    • When playing as at least 2.5-point favorites this season, the 49ers have an ATS record of 5-6.
    • Los Angeles has been an underdog by 2.5 points or more seven times this season, and covered the spread in three of those contests.
    • So far this season, eight out of the 49ers' 13 games have hit the over.
    • Rams games have hit the over seven out of 13 times this year.

    Looking for NFL tickets? Head to StubHub today and see your team live.